Open AccessQuinone oxidoreductase 1 is overexpressed in gastric cancer and associated with outcome of adjuvant chemotherapy and survival
Author(s) -
Zhig Jiang,
Syed Minhaj Uddin Ahmed,
Qin-Chuan Wang,
Shi H,
Xiuwen Tang
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i22.3085
Subject(s) - cancer , medicine , chemotherapy , biomarker , oncology , immunohistochemistry , stage (stratigraphy) , pathological , cancer research , gastroenterology , pathology , biology , paleontology , biochemistry
Quinine oxidoreductase 1 (NQO1) plays a vital role in protecting normal cells against oxidative damage and electrophilic attack. It is highly expressed in many solid tumors, suggesting a role in cancer development and progression. However, the role of NQO1 in gastric cancer and its effect on cancer development and prognosis have not been fully investigated.