Open AccessCase series of three patients with hereditary diffuse gastric cancer in a single family: Three case reports and review of literature
Author(s) -
Masahiro Hirakawa,
Kohichi Takada,
Masanori Sato,
Chisa Fujita,
Naotaka Hayasaka,
Takayuki Nobuoka,
Shintaro Sugita,
Aki Ishikawa,
Miyako Mizukami,
Hiroyuki Ohnuma,
Kazuyuki Murase,
Koji Miyanishi,
Masayoshi Kobune,
Ichiro Takemasa,
Tadashi Hasegawa,
Akihiro Sakurai,
Junji Kato
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i42.6689
Subject(s) - cdh1 , medicine , cancer syndrome , cancer , missense mutation , germline mutation , family history , signet ring cell carcinoma , esophagogastroduodenoscopy , genetic counseling , mutation , pathology , genetics , gene , adenocarcinoma , biology , endoscopy , cadherin , cell
Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome often associated with germline mutations in the CDH1 gene. However, the frequency of CDH1 mutations is low in patients with HDGC in East Asian countries. Herein, we report three cases of HDGC harboring a missense CDH1 variant, c.1679C>G, from a single Japanese family.