Open AccessFocus on gastroesophageal reflux disease in patients with cystic fibrosis
Author(s) -
Annarita Bongiovanni,
Sara Manti,
Giuseppe Fabio Parisi,
Maria Papale,
Enza Mulè,
Novella Rotolo,
Salvatore Leonardi
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i41.6322
Subject(s) - reflux , cystic fibrosis , medicine , disease , gerd , gastroenterology , focus (optics) , physics , optics
Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder in cystic fibrosis (CF), and based on various studies, its prevalence is elevated since childhood. There are several pathogenetic mechanisms on the basis of association between CF and GERD. However, there are no specific guidelines for GERD in CF patients, so diagnosis is based on guidelines performed on patients not affected by CF. The aim of this review is to provide the pathophysiology, diagnostic and therapeutic options, complications, and future directions in the management of GERD patients with CF.