Open AccessNew approach of medicinal herbs and sulfasalazine mixture on ulcerative colitis induced by dextran sodium sulfate
Author(s) -
MiRae Shin,
Hae-Jin Park,
Bu-Il Seo,
SeongSoo Roh
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i35.5272
Subject(s) - sulfasalazine , ulcerative colitis , colitis , traditional medicine , medicine , dextran , pharmacology , chemistry , gastroenterology , chromatography , disease
Sulfasalazine has been used as a standard-of-care in ulcerative colitis for decades, however, it results in severe adverse symptoms, such as hepatotoxicity, blood disorders, male infertility, and hypospermia. Accordingly, the new treatment strategy has to enhance pharmacological efficacy and stimultaneously minimize side effects.