Open AccessResveratrol alleviates intestinal mucosal barrier dysfunction in dextran sulfate sodium-induced colitis mice by enhancing autophagy
Author(s) -
Hanghai Pan,
Xinxin Zhou,
Yingyu Ma,
Wensheng Pan,
Fei Zhao,
Mosang Yu,
Jingquan Liu
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i33.4945
Subject(s) - autophagy , colitis , resveratrol , intestinal mucosa , chemistry , dextran , medicine , pharmacology , immunology , biochemistry , apoptosis
Intestinal mucosal barrier dysfunction plays an important role in the pathogenesis of ulcerative colitis (UC). Recent studies have revealed that impaired autophagy is associated with intestinal mucosal dysfunction in the mucosa of colitis mice. Resveratrol exerts anti-inflammatory functions by regulating autophagy.