Open AccessMiR-301a transcriptionally activated by HIF-2α promotes hypoxia-induced epithelial-mesenchymal transition by targeting TP63 in pancreatic cancer
Author(s) -
Kun-Dong Zhang,
Bin Hu,
Gang Cen,
Yuhan Yang,
Weiwei Chen,
Zengya Guo,
Xiaofeng Wang,
Qian Zhao,
Zhengjun Qiu
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i19.2349
Subject(s) - epithelial–mesenchymal transition , pancreatic cancer , microrna , cancer research , metastasis , western blot , biology , cell migration , cancer cell , cell , cancer , gene , biochemistry , genetics
Pancreatic cancer (PC) is one of the deadliest cancers worldwide. PC metastasis involves a complex set of events, including epithelial-mesenchymal transition (EMT), that increase tumor cell invasiveness. Recent evidence has shown that hypoxia is a major EMT regulator in pancreatic cancer cells and facilitates metastasis; however, the mechanisms remain elusive.