Open AccessMesencephalic astrocyte-derived neurotrophic factor ameliorates steatosis in HepG2 cells by regulating hepatic lipid metabolism
Author(s) -
Miao He,
Cong Wang,
Long Xiao,
Jia Peng,
Dongfang Liu,
Gang Yang,
Michael D. Jensen,
Li Li Zhang
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i10.1029
Subject(s) - steatosis , lipid metabolism , neurotrophic factors , astrocyte , brain derived neurotrophic factor , endocrinology , medicine , metabolism , energy metabolism , hepatic stellate cell , chemistry , biology , central nervous system , receptor
Nonalcoholic fatty liver disease (NAFLD) is a global metabolism-associated liver disease. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a newly discovered secreted protein that is involved in metabolic homeostasis. However, much remains to be discovered about its function in hepatic lipid metabolism; thus, we assessed whether MANF could regulate hepatic metabolism.