Open AccessLiver stem cells: Plasticity of the liver epithelium
Author(s) -
Atsunori Tsuchiya,
Wei-Yu Lu
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i9.1037
Subject(s) - regeneration (biology) , liver regeneration , stem cell , liver injury , reprogramming , biology , population , epithelium , pathology , microbiology and biotechnology , medicine , cell , endocrinology , genetics , environmental health
The liver has a high regenerative capacity after acute liver injury, but this is often impaired during chronic liver injury. The existence of a dedicated liver stem cell population that acts as a source of regeneration during chronic liver injury has been controversial. Recent advances in transgenic models and cellular reprogramming have provided new insights into the plasticity of the liver epithelium and directions for the development of future therapies. This article will highlight recent findings about the cellular source of regeneration during liver injury and the advances in promoting liver regeneration.