Open AccessCircular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a
Author(s) -
Zhipeng Qu,
Chi Zhang,
Jianxin Ma,
Hui Ren,
Yu Sun,
Jinghua Xu
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i35.5300
Subject(s) - colorectal cancer , microrna , transfection , cancer , biology , circular rna , cancer research , small interfering rna , lung cancer , cell culture , microbiology and biotechnology , pathology , medicine , gene , genetics
Circular RNAs (circRNAs) are considered to be highly stable due to the closed structure, which are predominately correlated with the development and progression of a wide variety of cancers. Colon cancer is one of the most common malignancies worldwide. A recent study demonstrated the upregulated expression of circPIP5K1A in non-small cell lung cancer. However, few studies have investigated the relationship between circ_0014130 level and colon cancer. Therefore, elucidating the underlying mechanisms of circPIP5K1A's role may help with the identification of novel diagnostic and therapeutic targets for colon cancer.