Open AccessPrediction of Crohn’s disease aggression throughNOD2/CARD15gene sequencing in an Australian cohort
Author(s) -
Maneesha Bhullar,
Finlay Macrae,
Gregor J. Brown,
M. Yao Smith,
Ken Sharpe
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i17.5008
Subject(s) - nod2 , crohn's disease , cohort , exon , medicine , allele frequency , allele , mutation , gastroenterology , biology , genetics , gene , disease
To investigate the association between mutations in oligomerisation domain 2/caspase recruitment domains 15 (NOD2/CARD15) and the natural history of Crohn's disease (CD) to identify patients who would benefit from early aggressive medical intervention.