Open AccessMetabonomic studies of pancreatic cancer response to radiotherapy in a mouse xenograft model using magnetic resonance spectroscopy and principal components analysis
Author(s) -
Xin He,
Wen Tao Li,
Yajuan Gu,
Bo Yang,
HongWen Deng,
Yi Hua Yu,
Wei Peng
Publication year - 2013
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v19.i26.4200
Subject(s) - phosphocholine , creatine , pancreatic cancer , choline , chemistry , pancreas , taurine , valine , alanine , radiation therapy , magic angle spinning , nuclear magnetic resonance spectroscopy , cancer , medicine , cancer research , pathology , biochemistry , amino acid , phospholipid , organic chemistry , membrane , phosphatidylcholine
To investigate the metabolic profiles of xenograft pancreatic cancer before and after radiotherapy by high-resolution magic angle spinning proton magnetic resonance spectroscopy (HRMAS (1)H NMR) combined with principal components analysis (PCA) and evaluate the radiotherapeutic effect.