Open AccessTargeting X-linked inhibitor of apoptosis protein inhibits pancreatic cancer cell growth through p-Akt depletion
Author(s) -
Chun Jiang,
Xiaoping Yi,
Hong Shen,
Yixiong Li
Publication year - 2012
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v18.i23.2956
Subject(s) - xiap , apoptosis , cancer research , mtt assay , protein kinase b , pancreatic cancer , cell growth , inhibitor of apoptosis , microbiology and biotechnology , small hairpin rna , biology , cell culture , gemcitabine , chemistry , cancer , programmed cell death , caspase , gene knockdown , biochemistry , genetics
To determine whether lentivirus-mediated shRNA targeting the X-linked inhibitor of apoptosis protein (XIAP) gene could be exploited in the treatment of pancreatic cancer.