Open AccessEnhancement of CTLs induced by DCs loaded with ubiquitinated hepatitis B virus core antigen
Author(s) -
Jianhua Chen,
Yi Yu,
Xiaohua Chen,
Honghong Liu,
Guoqing Zang,
Zhenghao Tang
Publication year - 2012
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v18.i12.1319
Subject(s) - hbcag , cytotoxic t cell , cd86 , antigen , virology , biology , hepatitis b virus , ctl* , microbiology and biotechnology , cd80 , t cell , immunology , virus , immune system , cd8 , cd40 , hbsag , in vitro , biochemistry
To investigate whether hepatitis B virus (HBV) could induce a hepatitis B virus core antigen (HBcAg)-specific cytotoxic T lymphocyte (CTL) response in vitro by dendritic cells (DCs) transduced with lentiviral vector-encoding ubiquitinated hepatitis B virus core antigen (LV-Ub-HBcAg).