Open AccessPrevention and management of non-steroidal anti-inflammatory drugs-induced small intestinal injury
Author(s) -
Sung Chul Park,
Hoon Jai Chun,
Chang Don Kang,
Donggeun Sul
Publication year - 2011
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v17.i42.4647
Subject(s) - medicine , capsule endoscopy , enteropathy , gastroenterology , asymptomatic , perforation , enteroscopy , drug , pathogenesis , endoscopy , pharmacology , materials science , disease , punching , metallurgy
Non-steroidal anti-inflammatory drug (NSAID)-induced small bowel injury is a topic that deserves attention since the advent of capsule endoscopy and balloon enteroscopy. NSAID enteropathy is common and is mostly asymptomatic. However, massive bleeding, stricture, or perforation may occur. The pathogenesis of small intestine injury by NSAIDs is complex and different from that of the upper gastrointestinal tract. No drug has yet been developed that can completely prevent or treat NSAID enteropathy. Therefore, a long-term randomized study in chronic NSAID users is needed.