Open AccessMK615 decreases RAGE expression and inhibits TAGE-induced proliferation in hepatocellular carcinoma cells
Author(s) -
Yuhki Sakuraoka,
Tokihiko Sawada,
Toshie Okada,
Takayuki Sakai,
Yoshihide Miura,
Katsuya Hiraishi,
Tatsushi Ohsawa,
Masakazu Adachi,
Junichi Takino,
Masayoshi Takeuchi,
Keiichi Kubota
Publication year - 2010
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v16.i42.5334
Subject(s) - rage (emotion) , glycation , flow cytometry , hepatocellular carcinoma , receptor , endocrinology , medicine , blot , cell growth , biology , andrology , chemistry , microbiology and biotechnology , gene , biochemistry , neuroscience
To investigate the proliferative effect of advanced glycation end-products (AGEs) and the role of their cellular receptor (RAGE) on hepatocellular carcinoma (HCC) cells, and the inhibitory effects of MK615, an extract from Japanese apricot, against AGEs were also evaluated.