Open AccessTwo novel germline mutations of MLH1 and investigation of their pathobiology in hereditary non-polyposis colorectal cancer families in China
Author(s) -
ChaoFu Wang,
Xiao Zhou,
Tai Ming Zhang,
Ye Xu,
San Jun Cai,
Da Shi
Publication year - 2007
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v13.i46.6254
Subject(s) - mlh1 , microsatellite instability , germline mutation , germline , biology , genetics , exon , mutation , colorectal cancer , cancer research , microsatellite , cancer , microbiology and biotechnology , gene , dna mismatch repair , allele
To detect germline mutations of MLH1, and investigate microsatellite instability and expression of MLH1 in tumor tissues of hereditary non-polyposis colorectal cancer (HNPCC) with two novel germline mutations, and further investigate the pathobiology of the two novel mutations of MLH1.