Open AccessPathophysiology of alcoholic pancreatitis: An overview
Author(s) -
Parimal Chowdhury,
Priya Gupta
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i46.7421
Subject(s) - pancreatitis , medicine , genetic predisposition , oxidative stress , ethanol metabolism , acute pancreatitis , alcohol , pathophysiology , alcohol consumption , pancreatic injury , signal transduction , bioinformatics , gastroenterology , biology , disease , metabolism , genetics , biochemistry
Use of alcohol is a worldwide habit regardless of socio-economic background. Heavy alcohol consumption is a potential risk factor for induction of pancreatitis. The current review cites the updated literature on the alcohol metabolism, its effects on gastrointestinal and pancreatic function and in causing pancreatic injury, genetic predisposition of alcohol induced pancreatitis. Reports describing prospective mechanisms of action of alcohol activating the signal transduction pathways, induction of oxidative stress parameters through the development of animal models are being presented.