Open AccessDown-regulation of survivin expression by small interfering RNA induces pancreatic cancer cell apoptosis and enhances its radiosensitivity
Author(s) -
Heng Guan,
Xingnan Xue,
Zhijun Dai,
Xijing Wang,
Ang Li,
Zike Qin
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i18.2901
Subject(s) - survivin , small interfering rna , radiosensitivity , transfection , lipofectamine , apoptosis , rna interference , microbiology and biotechnology , cancer research , biology , gene silencing , gene knockdown , cell culture , chemistry , rna , medicine , gene , vector (molecular biology) , recombinant dna , radiation therapy , biochemistry , genetics
To investigate the inhibitory effect of small interfering RNA (siRNA) on the expression of survivin in pancreatic cancer cell line PC-2 and the role of siRNA in inducing PC-2 cell apoptosis and enhancing its radiosensitivity.