Open AccessUpregulation of human telomerase reverse transcriptase mRNA expression byin vitrotransfection of hepatitis B virus X gene into human hepatocarcinoma and cholangiocarcinoma cells
Author(s) -
Zhen Qu
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i36.5627
Subject(s) - hbx , transfection , microbiology and biotechnology , telomerase reverse transcriptase , biology , telomerase , cell culture , expression vector , gene expression , gene , recombinant dna , biochemistry , genetics
To study the changes of human telomerase reverse transcriptase (hTERT) mRNA expression in human hepatocarcinoma cell lines (HepG2) and cholangiocarcinoma cell lines (QBC939) after HBx gene transfection and to illustrate the significance of transcriptional regulation of hTERT gene by HBx gene in the carcinogenesis.