Open AccessEphrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells
Author(s) -
Christian Hafner,
Stefanie Meyer,
Ilja Hagen,
Bernd Becker,
Alexander Roesch,
Míchael Landthaler,
Thomas Vogt
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i29.4511
Subject(s) - ephrin , signal transduction , microbiology and biotechnology , erythropoietin producing hepatocellular (eph) receptor , biology , downregulation and upregulation , focal adhesion , gene expression , gene , genetics , receptor tyrosine kinase
Eph receptors and ephrin ligands play a pivotal role in development and tissue maintenance. Since previous data have indicated an involvement of ephrin-B2 in epithelial healing, we investigated the gene expression and downstream signaling pathways induced by ephrin-B mediated cell-cell signaling in intestinal epithelial cells.