Open AccessCytotoxic effect of a non-peptidic small molecular inhibitor of the p53-HDM2 interaction on tumor cells
Author(s) -
Wendong Li,
Mi-Juan Wang,
Fang Ding,
Dali Yin,
Zhihua Liu
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i19.2927
Subject(s) - ht1080 , flow cytometry , mtt assay , cytotoxic t cell , microbiology and biotechnology , wild type , mutant , cell cycle , biology , apoptosis , cancer research , western blot , fibrosarcoma , cytotoxicity , chemistry , biochemistry , tumor cells , genetics , in vitro , gene
To investigate if non-peptidic small molecular inhibitors of the p53-HDM2 interaction could restore p53 function and kill tumor cells.