Open AccessCo-mutation of p53,K-rasgenes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer
Author(s) -
Zhi Zhong Pan,
De Sen Wan,
Gong Chen,
Li Ren Li,
Zhen Lü,
Bi Huang
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i24.3688
Subject(s) - exon , gene mutation , mutation , gene , biology , mutation rate , microbiology and biotechnology , single strand conformation polymorphism , colorectal cancer , cancer research , immunohistochemistry , cancer , genetics , immunology
To determine the accuracy of p53 gene mutations predicted by overexpression of p53 protein immunohistochemically, and to investigate the co-mutation of p53 and K-ras genes in rectal cancer and its effect on promoting malignant biologic behaviors of tumors.