Open AccessCOX-2 expression and tumor angiogenesis in colorectal cancer
Author(s) -
Aiwen Wu,
Jin Gu,
Zhen-Fu Li,
Jiafu Ji,
Guang-wei Xu
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i16.2323
Subject(s) - colorectal cancer , medicine , angiogenesis , immunohistochemistry , proportional hazards model , carcinogenesis , cancer , oncology , cyclooxygenase , tissue microarray , pathology , cancer research , biology , enzyme , biochemistry
Cyclooxygenase-2 (COX-2) is one of the rate-limiting enzymes in metabolism of arachidonic acid, and COX-2 inhibitors demonstrate preventive effects on cancer, especially on colorectal cancer. The underlying mechanism remains unclear. The aim of this study was to illustrate the relationship between angiogenesis and COX-2 in carcinogenesis of colorectal cancer.