Open AccessInsulin is necessary for the hypertrophic effect of cholecystokinin-octapeptide following acute necrotizing experimental pancreatitis
Author(s) -
Péter Hegyi,
Zoltán Rakonczay,
Réka Sári,
László Czakó,
Norbert Farkas,
Csaba Góg,
József Németh,
János Lonovics,
Tamás Takács
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i15.2275
Subject(s) - medicine , endocrinology , insulin , cholecystokinin , diabetes mellitus , amylase , streptozotocin , pancreas , pancreatitis , lipase , trypsinogen , acute pancreatitis , chemistry , trypsin , enzyme , biochemistry , receptor
In previous experiments we have demonstrated that by administering low doses of cholecystokinin-octapeptide (CCK-8), the process of regeneration following L-arginine (Arg)-induced pancreatitis is accelerated. In rats that were also diabetic (induced by streptozotocin, STZ), pancreatic regeneration was not observed. The aim of this study was to deduce whether the administration of exogenous insulin could in fact restore the hypertrophic effect of CCK-8 in diabetic-pancreatitic rats.