Open AccessPLASMA LEVELS OFSERUM METALLOPROTEINASES MMP-9, MMP-2 AND TISSUEINHIBITORSTIMP-2 IN NEWBORNS WITH NECROTIZING ENTEROCOLITIS
Author(s) -
I.N. Khvorostov,
И. Е. Смирнов
Publication year - 2021
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2021/11/1.17
Subject(s) - necrotizing enterocolitis , matrix metalloproteinase , gastroenterology , pathogenesis , medicine , elastase , sepsis , chemistry , enzyme , biochemistry
The analysis of the balance of elastase (MMP-2, MMP-9) and TIMP-4 was performed in order to determine its involvement in the pathogenesis of NEC. A progressive duration of NEC with sepsis is accompanied by increased serum concentrations of MMP-9, MMP-2 and TIMP-4. Increases in concentrations of MMP-2>503 ng/ml, MMP-9>812 ng/ml TIMP-4>1404 ng/ml can be regarded as statistically significant predictors of fatal outcome of NEC. The proposed method for determination of the outcomes of NEC in newborns is characterized by high sensitivity (94%) and specificity (87%).