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On average, arterial oxygen saturation measured by pulse oximetry (SpO 2 ) is higher in hypoxemia than the true oxygen saturation measured invasively (SaO 2 ), thereby increasing the risk of occult hypoxemia. In the current article, measurements of SpO 2 on 17 cyanotic newborns were performed by means of a Nellcor pulse oximeter (POx), based on light with two wavelengths in the red and infrared regions (660 and 900 nm), and by means of a novel POx, based on two wavelengths in the infrared region (761 and 820 nm). The SpO 2 readings from the two POxs showed higher values than the invasive SaO 2 readings, and the disparity increased with decreasing SaO 2 . SpO 2 measured using the two infrared wavelengths showed better correlation with SaO 2 than SpO 2 measured using the red and infrared wavelengths. After appropriate calibration, the standard deviation of the individual SpO 2 -SaO 2 differences for the two-infrared POx was smaller (3.6%) than that for the red and infrared POx (6.5%, p &lt; 0.05). The overestimation of SpO 2 readings in hypoxemia was explained by the increase in hypoxemia of the optical pathlengths-ratio between the two wavelengths. The two-infrared POx can reduce the overestimation of SpO 2 measurement in hypoxemia and the consequent risk of occult hypoxemia, owing to its smaller increase in pathlengths-ratio in hypoxemia.

Overestimation of Oxygen Saturation Measured by Pulse Oximetry in Hypoxemia. Part 1: Effect of Optical Pathlengths-Ratio Increase