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The fracture resistance of 3-unit interim fixed dental prostheses (IFDPs) fabricated using digital light processing (DLP) additive technology with different printing parameters is neglected. Therefore, this study investigates the effect of different printing orientations and different post-curing times on the fracture resistance of 3-unit IFDPs fabricated from two three-dimensional (3D) printed resins, NextDent, C&amp;B (CB), ASIGA, and DentaTOOTH. A 3-unit dye was scanned, and an IFDP was designed. A total of 300 specimens (150/materials, n = 10) were printed and divided into three groups according to printing orientations (0°, 45°, 90°) per material. Each orientation was subdivided into five groups ( n = 10) considering the post-curing time (green state as control, 30, 60, 90, and 120 min). All specimens underwent thermocycling (5000 cycles). Each specimen was fitted onto the die and loaded until fracture using a universal testing machine with a loading rate of 1 m/min. Data were analyzed using ANOVA and post hoc Tukey test (α = 0.05). The result showed that printing orientation had a significant effect on the fracture load for both ASIGA and NextDent materials ( p &lt; 0.05). The highest fracture load was recorded with 45° orientation, followed by 0° orientation and 90° orientation showed the lowest values per respective post-curing time. Post-curing time increased the fracture load ( p &lt; 0.05). Post-curing time had a positive effect on the fracture load. As the post-curing time increased, the fracture resistance load increased ( p &lt; 0.05), with 90 and 120 min showing the highest fracture load. The 0° and 45° printing orientations have a high fracture load for 3D-printed IFDPs, and an increased post-curing time is recommended.

Fracture Load of 3D-Printed Interim Three-Unit Fixed Dental Prostheses: Impact of Printing Orientation and Post-Curing Time