English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Novel monomethoxy poly(ethylene glycol) ( m PEG) modified hydroxylated tung oil (HTO), denoted as m PEG-HTO- m PEG, was designed and synthesized for drug delivery. m PEG-HTO- m PEG consists of a hydroxylated tung oil center joined by two m PEG blocks via a urethane linkage. The properties of m PEG-HTO- m PEG were affected by the length of the mPEG chain. Three m PEG with different molecular weights were used to prepare m PEG-HTO- m PEG. The obtained three m PEG-HTO- m PEG polymers were characterized by nuclear magnetic resonance (NMR), Fourier transformation infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and gel permeation chromatography (GPC), respectively. Furthermore, the particle sizes of m PEG-HTO- m PEG micelles were evaluated by dynamic light scattering (DLS) and transmission electron microscope (TEM). A critical aggregation concentration (CAC) ranged from 7.28 to 11.73 mg/L depending on the chain length of mPEG. The drug loading and release behaviors of m PEG-HTO- m PEG were investigated using prednisone acetate as a model drug, and results indicated that hydrophobic prednisone acetate could be effectively loaded into m PEG-HTO- m PEG micelles and exhibited a long-term sustained release. Moreover, compared with HTO, m PEG-HTO- m PEG had no obvious cytotoxicity to HeLa and L929 cells. Therefore, monomethoxy poly(ethylene glycol) modified hydroxylated tung oil m PEG-HTO- m PEG may be a promising drug carrier.

Novel Monomethoxy Poly(Ethylene Glycol) Modified Hydroxylated Tung Oil for Drug Delivery