English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Assessment of glomerular filtration rate (GFR) is necessary for dose adjustments of beta-lactam that are excreted by the kidneys, such as meropenem. The aim of this study was to compare the daily dose of 24 h-continuous infusion (CI) meropenem when GFR was calculated by means of measured creatinine clearance (mCL CR ) or estimated by the CKDEPI (eGFR CKDEPI ), Cockcroft-Gault (eGFR CG ), and MDRD (eGFR MDRD ) equations. Adult critically ill patients who underwent therapeutic drug monitoring (TDM) for the assessment of 24 h-CI meropenem steady state concentration (Css) and for whom a 24 h-urine collection was performed were retrospectively enrolled. Meropenem clearance (CL M ) was regressed against mCL CR , and meropenem daily dose was calculated based on the equation infusion rate = daily dose/CL M . eGFR CKDEPI , eGFR CG , and eGFR CKDEPI were regressed against mCL CR in order to estimate CL M . Forty-six patients who provided 133 meropenem Css were included. eGFR CKDEPI overestimated mCL CR up to 90 mL/min, then mCL CR was underestimated. eGFR CG and eGFR MDRD overestimated mCL CR across the entire range of GFR. In critically ill patients, dose adjustments of 24 h-CI meropenem should be based on mCL CR . Equations for estimation of GFR may lead to gross under/overestimates of meropenem dosages. TDM may be highly beneficial, especially for critically ill patients with augmented renal clearance.

pharmaceutics

Measuring Creatinine Clearance Is the Most Accurate Way for Calculating the Proper Continuous Infusion Meropenem Dose for Empirical Treatment of Severe Gram-Negative Infections among Critically Ill Patients