English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

A methanol extract of the flowers of Mammea siamensis (Miq.) T. Anders. (Calophyllaceae) showed anti-proliferative activity against human prostate carcinoma LNCaP cells (IC 50 = 2.0 µg/mL). Two new coumarin-related polysubstituted benzofurans, mammeasins P ( 1 ) and Q ( 2 ), and a known polysubstituted coumarin mammea B/AC cyclo F ( 39 ) were isolated from the extract along with 44 previously reported polysubstituted coumarin constituents ( 3 - 38 and 40 - 47 ). The structures of two new compounds ( 1 and 2 ) were determined based on their spectroscopic properties derived from the physicochemical evidence including NMR and MS analyses and taking the plausible generative pathway into account. Among the coumarin constituents, mammeasins A ( 3 , IC 50 = 1.2 µM) and B ( 4 , 0.63 µM), sugangin B ( 18 , 1.5 µM), kayeassamins E ( 24 , 3.0 µM) and G ( 26 , 3.5 µM), and mammeas E/BA ( 40 , 0.88 µM), E/BB ( 41 , 0.52 µM), and E/BC ( 42 , 0.12 µM) showed relatively potent anti-proliferative activity.

pharmaceuticals

Structures of Mammeasins P and Q, Coumarin-Related Polysubstituted Benzofurans, from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Anti-Proliferative Activity of Coumarin Constituents against Human Prostate Carcinoma Cell Line LNCaP