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H 2 S (hydrogen sulfide) protects cerebral vasodilatation and endothelial cells against oxygen-glucose deprivation/reoxygenation injury via the inhibition of the RhoA-ROCK pathway and ROCK 2 expression. However, the inhibitory mechanism of H 2 S on ROCK 2 expression is still unclear. The study aimed to investigate the target and mechanism of H 2 S in inhibition of ROCK 2 .

Protection of H2S against Hypoxia/Reoxygenation Injury in Rat Hippocampal Neurons through Inhibiting Phosphorylation of ROCK2 at Thr436 and Ser575