English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The molecular prognostic markers of metastasis are important for personalized approaches to clear cell renal cell carcinoma (ccRCC) treatment but markers for practical use are still missing. To address this gap we studied the expression of ten genes- CA9 , NDUFA4L2 , VWF , IGFBP3 , BHLHE41 , EGLN3 , SAA1 , CSF1R , C1QA , and FN1-through RT-PCR, in 56 ccRCC patients without metastases and with metastases. All of these, excluding CSF1R , showed differential and increased (besides SAA1 ) expression in non-metastasis tumors. The gene expression levels in metastasis tumors were decreased, besides CSF1R , FN1 (not changed), and SAA1 (increased). There were significant associations of the differentially expressed genes with ccRCC metastasis by ROC analysis and the Fisher exact test. The association of the NDUFA4L2 , VWF , EGLN3 , SAA1 , and C1QA expression with ccRCC metastasis is shown for the first time. The CA9 , NDUFA4L2 , BHLHE4 , and EGLN3 were distinguished as the strongest candidates for ccRCC metastasis biomarkers. We used an approach that presupposed that the metastasis marker was the expression levels of any three genes from the selected panel and received sensitivity (88%) and specificity (73%) levels with a relative risk of RR &gt; 3. In conclusion, a panel of selected genes-the candidates in biomarkers of ccRCC metastasis-was created for the first time. The results might shed some light on the ccRCC metastasis processes.

The Genes—Candidates for Prognostic Markers of Metastasis by Expression Level in Clear Cell Renal Cell Cancer