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Background  Epidermal growth factor receptor (EGFR) mutations have a low incidence in squamous cell lung cancer (SqCLC), and the clinical efficacy of EGFR tyrosine kinase inhibitors (TKIs) in  EGFR -mutated SqCLC is far less than that in  EGFR -mutated lung adenocarcinoma. The treatment strategy for patients with  EGFR- mutated non-small cell lung cancer who are refractory to EGFR TKIs has become a current dilemma and challenge.    Case Presentation  A case of a 69-year-old male patient suffering from intermittent cough and hemoptysis was diagnosed with  EGFR -mutated advanced SqCLC (stage cT2bN2M1). The patient was treated with camrelizumab alone after five courses of different systemic therapies and achieved a partial response, with an eminent progression-free survival of more than 24 months. Grade 1 to 2 reactive cutaneous capillary endothelial proliferation and mild pruritus were observed during the treatment. No other immune-related adverse events were observed.    Conclusion  Monotherapy of immune-checkpoint inhibitors may be considered as a later-line option for  EGFR -mutated advanced SqCLC patients with PD-L1 expression.

frontiers in oncology

Case Report: Opportunities and Challenges of Immunotherapy in Heavily-Treated EGFR-Mutant Advanced Squamous Cell Lung Carcinoma After Progression on EGFR-TKIs and Chemotherapy