Open AccessOvarian Tissue-Based Hormone Replacement Therapy Recovers Menopause-Related Signs in Mice
Author(s) -
Dahyeon Yoo,
Nanum Chung,
Jungyoung Yoo,
Chae Young Song,
Chul Ju Yang,
Hye Won Youm,
Kangwon Lee,
Jin Hyun Jun,
Jaewang Lee,
Jung Ryeol Lee
Publication year - 2022
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2022.63.7.648
Subject(s) - medicine , menopause , hormone replacement therapy (female to male) , osteoporosis , ovariectomized rat , transplantation , bone mineral , atrophy , bone density , hormone , ovarian tissue cryopreservation , adipose tissue , estrogen , endocrinology , fertility preservation , testosterone (patch) , fertility , population , environmental health
In women, menopause manifests with a variety of symptoms related to sex-hormone deficiency. Supplementing steroid hormones with pharmacological drugs has been widely practiced. However, considering the possible complications associated with artificial hormone therapy, studies have been conducted to find an alternative to pharmacological hormone replacement therapy. Accordingly, this study aimed to evaluate the efficacy of tissue-based hormone replacement therapy (tHRT) for treating post-menopausal signs and symptoms.