Open AccessCatalpol Inhibits Tregs-to-Th17 Cell Transdifferentiation by Up-Regulating Let-7g-5p to Reduce STAT3 Protein Levels
Author(s) -
Yu-Xi Di,
Mingfei Zhang,
YiChang Chen,
Rong Sun,
Meiyu Shen,
Feng-Xiang Tian,
Pei Yang,
Feiya Qian,
Lingling Zhou
Publication year - 2022
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2022.63.1.56
Subject(s) - transdifferentiation , stat3 , rar related orphan receptor gamma , arthritis , interleukin 17 , flow cytometry , chemistry , immunology , cellular differentiation , western blot , microbiology and biotechnology , biology , inflammation , stem cell , signal transduction , immune system , gene , biochemistry , foxp3
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, and Th17 cells are key factors in the pathogenesis of human inflammatory conditions, such as RA. Catalpol (CAT), a component in Rehmanniae Radix (RR), has been found to regulate human immunity. However, the effects of CAT on Th17 cell differentiation and improvement of RA are not clear.