Open AccessHypoxia Regulates the Extracellular Matrix via Mitogen-Activated Protein Kinases Pathway in Cells Retrieved from the Human Intervertebral Disc
Author(s) -
Young Mi Kang,
Eun Jung Shin,
Byung Ho Lee,
Jihoon Yang,
Hwan Mo Lee,
Seong Hwan Moon
Publication year - 2021
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2021.62.8.734
Subject(s) - chondrocyte , microbiology and biotechnology , extracellular matrix , aggrecan , chemistry , kinase , hypoxia (environmental) , biochemistry , biology , oxygen , medicine , pathology , in vitro , osteoarthritis , organic chemistry , articular cartilage , alternative medicine
The present study aimed to identify the physiological characteristics of cells by investigating the change in gene expression and protein levels during extracellular matrix (ECM) synthesis in the intervertebral disc (IVD) under hypoxic conditions.