Open AccessDownregulation of MicroRNA-495 Alleviates IL-1β Responses among Chondrocytes by Preventing SOX9 Reduction
Author(s) -
Soyeong Joung,
Dong Suk Yoon,
Sehee Cho,
Eun A. Ko,
Kyoung Mi Lee,
Kwang Hwan Park,
Jin Woo Lee,
SungHwan Kim
Publication year - 2021
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2021.62.7.650
Subject(s) - chondrocyte , mesenchymal stem cell , sox9 , downregulation and upregulation , gene knockdown , microrna , cartilage , chondrogenesis , blot , chemistry , microbiology and biotechnology , cancer research , in vitro , medicine , biology , apoptosis , gene expression , biochemistry , anatomy , gene
Our previous work demonstrated that miRNA-495 targets SOX9 to inhibit chondrogenesis of mesenchymal stem cells. In this study, we aimed to investigate whether miRNA-495-mediated SOX9 regulation could be a novel therapeutic target for osteoarthritis (OA) using an in vitro cell culture model.