Open AccessExpression of Organic Anion Transporting Polypeptides in an H-Ras 12V Transgenic Mouse Model of Spontaneous Hepatocellular Carcinoma
Author(s) -
Honsoul Kim,
Ji Sun Choi,
Dae Yeul Yu,
Hye Jin Choi
Publication year - 2021
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2021.62.7.622
Subject(s) - hccs , hepatocellular carcinoma , pathological , immunohistochemistry , pathology , h&e stain , gadoxetic acid , medicine , cancer research , chemistry , magnetic resonance imaging , gadolinium dtpa , radiology
Expression of organic anion transporting polypeptides (OATPs) 1B1/1B3 in hepatocellular carcinoma (HCC) induces a paradoxical enhancement of gadoxetic acid on liver magnetic resonance imaging (MRI). We examined the expression profile of OATPs with regard to tumor differentiation in a genetically modified H-Ras 12V mouse model of spontaneous HCC that undergoes multistep hepatocarcinogenesis with minimal inter-individual variation.