Open AccessSystemic Immunomodulatory Effects of Combinatorial Treatment of Thalidomide and Dexamethasone on T Cells and Other Immune Cells
Author(s) -
Eun Jee Kim,
Joon Ye Kim,
Hoon Young Choi,
Hyojung Lee,
Juhan Lee,
Myoung Soo Kim,
Yu Seun Kim,
Kyu Ha Huh,
Beom Seok Kim
Publication year - 2021
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2021.62.2.137
Subject(s) - immune system , cytotoxic t cell , mixed lymphocyte reaction , t cell , biology , flow cytometry , immunology , in vivo , antigen presenting cell , microbiology and biotechnology , chemistry , in vitro , biochemistry
In organ transplantation, the need for immune modulation rather than immune suppression has been emphasized. In this study, we investigated whether combinatorial treatments of with thalidomide (TM) and dexamethasone (DX) might be new approaches to induce systemic immunomodulation on T cells and other immune cells that regulate the expression of co-inhibitory molecules.