Open AccessHOTAIR Induces Methylation of PCDH10, a Tumor Suppressor Gene, by Regulating DNMT1 and Sponging with miR-148b in Gastric Adenocarcinoma
Author(s) -
Seung In Seo,
Jung-ho Yoon,
Hyo Joo Byun,
Sang Kil Lee
Publication year - 2021
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2021.62.2.118
Subject(s) - hotair , carcinogenesis , gene knockdown , cancer research , methylation , biology , dna methylation , microbiology and biotechnology , epigenetics , gene expression , downregulation and upregulation , long non coding rna , cancer , gene , genetics
HOX transcript antisense intergenic RNA (HOTAIR), as a long non-coding RNA, has been reported to regulate carcinogenesis by epigenetic mechanism in various cancers. Protocadherin 10 (PCDH10) is one of the well-known tumor suppressor genes, and is frequently methylated in gastric cancers (GC). We aimed to investigate the detailed pathway of how HOTAIR contributes to the target gene in gastric carcinogenesis.