Open AccessActivation of CpG-ODN-Induced TLR9 Signaling Inhibited by Interleukin-37 in U937 Human Macrophages
Author(s) -
Seong-Kyu Kim,
JungYoon Choe,
Ki-Yeun Park
Publication year - 2021
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2021.62.11.1023
Subject(s) - cpg oligodeoxynucleotide , tlr9 , u937 cell , tumor necrosis factor alpha , cytokine , small interfering rna , microbiology and biotechnology , transfection , chemistry , interleukin , biology , immunology , cell culture , in vitro , gene expression , dna methylation , biochemistry , genetics , gene
Interleukin-37 (IL-37) is an anti-inflammatory cytokine that inhibits a broad spectrum of inflammatory responses in various human cells, including neutrophils, macrophages, and endothelial cells. The aim of this study was to identify the role of IL-37 in toll-like receptor 9 (TLR9) signaling in human macrophages.