Open AccessCertain Polymorphisms in SP110 Gene Confer Susceptibility to Tuberculosis: A Comprehensive Review and Updated Meta-Analysis
Author(s) -
Shuai Zhang,
XueBin Wang,
Ya Di Han,
Chen Wang,
Ye Zhou,
Fang Zheng
Publication year - 2017
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2017.58.1.165
Subject(s) - meta analysis , confidence interval , subgroup analysis , single nucleotide polymorphism , snp , heterozygote advantage , allele , publication bias , genetic model , medicine , genetics , tuberculosis , genotype , biology , gene , pathology
Numerous studies have assessed the association of SP110 gene variants with tuberculosis (TB), but the results were inconsistent. Through a comprehensive review and meta-analysis, our study aimed to clarify the nature of genetic risks contributed by 11 polymorphisms for the development of TB.