Open AccessImmunoglobulin VH Chain Gene Analysis of Peripheral Blood IgM-Producing B Cells in Patients with Kawasaki Disease
Author(s) -
Hyun Hee Lee,
Jeon-Soo Shin,
Dong Soo Kim
Publication year - 2009
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2009.50.4.493
Subject(s) - kawasaki disease , antibody , superantigen , polymerase chain reaction , systemic vasculitis , medicine , pathogenesis , immunology , microbiology and biotechnology , b cell , gene , vasculitis , biology , t cell , disease , immune system , genetics , artery
Kawasaki disease is a systemic vasculitis, and its etiology and pathogenesis are still not clear. Our study was undertaken to investigate the characteristics of the activation of B cells in the peripheral blood of Kawasaki disease (KD) patients and evidence of stimulation by superantigens.