Open AccessImmune Checkpoint Inhibitor with or without Radiotherapy in Melanoma Patients with Brain Metastases: A Systematic Review and Meta-Analysis
Author(s) -
Pyeong Hwa Kim,
Chong Hyun Suh,
Ho Sung Kim,
Kyung Won Kim,
Dong Yeong Kim,
Eudocia Q. Lee,
Ayal A. Aizer,
Jeffrey P. Guenette,
Raymond Y. Huang
Publication year - 2021
Publication title -
korean journal of radiology/korean journal of radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.08
H-Index - 57
eISSN - 2005-8330
pISSN - 1229-6929
DOI - 10.3348/kjr.2020.0728
Subject(s) - medicine , radiation therapy , adverse effect , combination therapy , oncology , meta analysis , confidence interval , surgery
Immune checkpoint inhibitor (ICI) therapy has shown activity against melanoma brain metastases. Recently, promising results have also been reported for ICI combination therapy and ICI combined with radiotherapy. We aimed to evaluate radiologic response and adverse event rates of these therapeutic options by a systematic review and meta-analysis.