Open AccessImmunoglobulin G4-Related Lung Disease Mimicking Lung Cancer: Two Case Reports
Author(s) -
Dae Yun Park,
Su Young Kim,
Suk Hyun Bae,
Ji Young Lee
Publication year - 2022
Publication title -
daehan yeongsang uihak hoeji/daehan yeongsang ui haghoeji
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 3
eISSN - 2288-2928
pISSN - 1738-2637
DOI - 10.3348/jksr.2021.0158
Subject(s) - medicine , igg4 related disease , lung cancer , differential diagnosis , lung , pathology , nodule (geology) , radiology , disease , biopsy , metastasis , antibody , cancer , immunology , paleontology , biology
Immunoglobulin G4 (IgG4)-related disease is a rare systemic fibroinflammatory condition characterized by elevated serum IgG4 levels and infiltration of IgG4-positive plasma cells in various organs. IgG4-related lung disease shows varied radiologic features on chest CT. Patients usually present with a solid nodule or mass mimicking lung cancer; therefore, distinguishing between IgG4-related disease and other conditions is often challenging. Additionally, co-existing radiologic findings of IgG4-related lung disease may mimic metastasis or lymphangitic carcinomatosis of the lung. We report two cases of histopathologically confirmed IgG4-related lung disease mimicking lung cancer. Chest CT revealed a solid nodule or mass with ancillary radiologic findings, which suggested lung cancer; therefore, IgG4-related lung disease was radiologically indistinguishable from lung cancer in both cases. Measurement of serum IgG4 levels and clinical evaluation to confirm involvement of various organs may be useful to establish the differential diagnosis. However, surgical biopsy evaluation is needed for confirmation.