Open AccessSevere Osteomyelitis as a Complication of Tokyo-172 BCG Vaccination
Author(s) -
Hyo Jin Kwon,
Bo Hyun Chung,
Byung Min Choi,
Kyoung Un Park,
Yun Kyung Kim
Publication year - 2012
Publication title -
journal of korean medical science/journal of korean medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.743
H-Index - 66
eISSN - 1598-6357
pISSN - 1011-8934
DOI - 10.3346/jkms.2012.27.2.221
Subject(s) - medicine , osteomyelitis , complication , surgery , tuberculosis , vaccination , elbow , osteitis , biopsy , bcg vaccine , septic arthritis , chemotherapy , arthritis , pathology
The bacilli Calmette-Guérin (BCG) Tokyo-172 strain was considered to exhibit good protective efficacy with a low rate of unfavorable side effects. However, we describe a rare case of BCG osteomyelitis developed in an immunocompetent host who was given with BCG Tokyo-172 vaccine on the left upper arm by multipuncture method. A 9-month-old girl presented with progressive inability to move her right elbow and had radiographic evidence of septic elbow combined with osteomyelitis of right distal humerus. A biopsy from the site revealed chronic caseating granulomatous inflammation, positive for BCG Tokyo-172 strain on the multiplex polymerase chain reaction. The child had to undergo second surgical debridements and oral antituberculosis chemotherapy. There were no sequelae after 2 yr of follow-up. This complication, although uncommon, should be considered in the appropriate clinical setting.