Open AccessLong Term Follow-up Results of External Beam Radiotherapy as Primary Treatment for Retinoblastoma
Author(s) -
Soyoung Choi,
Misook Kim,
SungYul Yoo,
ChulKoo Cho,
Young Hoon Ji,
Kumbae Kim,
Youngseok Seo,
Kyung Duk Park,
JunAh Lee,
Tai-Won Lee
Publication year - 2010
Publication title -
journal of korean medical science/journal of korean medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.743
H-Index - 66
eISSN - 1598-6357
pISSN - 1011-8934
DOI - 10.3346/jkms.2010.25.4.546
Subject(s) - retinoblastoma , medicine , radiation therapy , external beam radiotherapy , surgery , visual acuity , complication , malignancy , external beam radiation , primary treatment , ophthalmology , brachytherapy , biochemistry , chemistry , gene
The authors reviewed their experiences of external beam radiotherapy (EBR) as an initial treatment in retinoblastoma patients to determine its long-term effect on subsequent tumor control and complications. A total of 32 eyes in 25 patients that underwent EBR for retinoblastoma were reviewed retrospectively. The patients consisted of 21 boys and 4 girls of median age at treatment of 7.1 months. Radiation doses ranged from 35 to 59.4 Gy. The 10-yr ocular and patient survivals were 75.4% and 92.3%, respectively. Nine of the 32 eyes progressed; 7 of these were enucleated and 2 were salvaged by focal treatment. According to the Reese-Ellsworth classification, 4 of 5 eyes of Group II, 13 of 16 Group III eyes, 2 of 4 Group IV eyes, and 5 of 7 Group V eyes were retained, and of the 32 eyes, 13 had visual acuity better than 20/200. Eleven patients experienced a radiation-induced complication. No patient developed a second malignancy during follow-up. Despite the limited number of patients enrolled, EBR may provide a mean of preserving eyeball and vision for some advanced lesions.