Open AccessHydroxycoumarin Grafted with Hydrazine: Synthesis, Structure Elucidation and Assessment of Antioxidant and Antibacterial Characteristics
Publication year - 2020
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac113.1039310401
Subject(s) - macromolecule , chemistry , proteus vulgaris , antibacterial activity , antioxidant , scavenger , hydrazine (antidepressant) , organic chemistry , nuclear chemistry , combinatorial chemistry , biochemistry , bacteria , escherichia coli , biology , genetics , gene
4-Hydroxycoumarin, as a natural organic compound, was structurally grafted onto a benzaldehyde by hydrazine. The chemical structure of grafted macromolecule was confirmed by FT-IR and NMR spectroscopy. The antibacterial activity of the synthesized grafted macromolecule against Staphyloccocus aureus, E. coli, Proteus vulgaris, Pseudomonas, and Klebsiella pneumoniae was assessed using a disc diffusion technique. The antioxidant activity of the grafted macromolecule was also highlighted using the superoxide-radical technique. The grafted macromolecule has high inhibition activity against all tested bacteria. The grafted macromolecule was a much more effective free radical scavenger than vitamin C.