English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Endothelial cells arranged on the vessel lumen are constantly stimulated by blood flow, blood pressure and pressure-induced cyclic stretch. These stimuli are sensed through mechanical sensory structures and converted into a series of functional responses through mechanotransduction pathways. The process will eventually affect vascular health. Therefore, there has been an urgent need to establish  in vitro  endothelial biomechanics and mechanobiology of models, which reproduce three-dimensional structure vascular system. In recent years, the rapid development in microfluidic technology makes it possible to replicate the key structural and functionally biomechanical characteristics of vessels. Here, we summarized the progress of microfluidic chips used for the investigation of endothelial biomechanics and mechanobiology of the vascular system. Firstly, we elucidated the contribution of shear stress and circumferential stress, to vascular physiology. Then, we reviewed some applications using microfluidic technology in angiogenesis and vasculogenesis, endothelial permeability and mechanotransduction, as well as the blood-brain barrier under these physical forces. Finally, we discussed the future obstacles in terms of the development and application of microfluidic vascular chips.

Microfluidic chips for the endothelial biomechanics and mechanobiology of the vascular system