Open AccessComparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms
Author(s) -
Lara Petricca,
Nour Chiki,
Layane Hanna-El-Daher,
Lorène Aeschbach,
Ritwik Burai,
Erik Stoops,
Mohamed-Bilal Fares,
Hilal A. Lashuel
Publication year - 2022
Publication title -
journal of parkinson's disease/journal of parkinson's disease (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.747
H-Index - 45
eISSN - 1877-718X
pISSN - 1877-7171
DOI - 10.3233/jpd-223285
Subject(s) - computational biology , biomarker , biology , bioinformatics , genetics
The development of therapeutics for Parkinson's disease (PD) requires the establishment of biomarker assays to enable stratifying patients, monitoring disease progression, and assessing target engagement. Attempts to develop diagnostic assays based on detecting levels of the α-synuclein (αSYN) protein, a central player in the pathogenesis of PD, have yielded inconsistent results.